BDBM50428286 DABRAFENIB::GSK2118436A

SMILES CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F

InChI Key InChIKey=BFSMGDJOXZAERB-UHFFFAOYSA-N

Data  25 IC50  4 EC50

PDB links: 6 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50428286   

TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50428286(DABRAFENIB | GSK2118436A)
Affinity DataIC50:  2nMAssay Description:Inhibition of human RIPK3 using MBP as substrate by [gamma33-ATP] based radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50428286(DABRAFENIB | GSK2118436A)
Affinity DataIC50:  250nMAssay Description:Inhibition of human full length N-terminal GST-tagged RIPK3 expressed in baculovirus infected sf9 insect cells assessed as reduction in MBP phosphory...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed